The Blow-Fill-Seal Technique has been developed so that formation of the container, filling and sealing takes place in a single machine under a controlled environment that enables the packaging of a pharmaceutical liquid in an aseptic manner.

As the container is made, filled and sealed within a single machine and the process is protected using a sterile air shower and additionally, all process media (solution, air etc.) are sterile filtered, the chance of contamination is very remote. Adding to the fact that during the whole cycle, open containers remain exposed to the clean room air for less than 1.5 seconds, the Blow-Fill-Seal technology becomes the process of choice where contamination of particle matter and microbial contamination is a primary concern.

Technical Date:

Extrusion

Blowing

The main forming mould closes and the bottom of plastic parison is 

sealed. The cutting knife cut the parison.The top of plastic parison is 

located by the open protecting clamp.Aseptic air continuously protects the open tube parison.

The plastic material is formed into containers as determined by the 

design of the mould by vacuum and/or aseptic compressed air.

Filling

The containers are filled immediately and the air in the container is 

displaced .In the filling process,the containers are protected by the 

aseptic air as Grade A.

Sealing

At the same time,the tube parison between top of plastic mould and 

the open protecting clamp remains semi-melting condition,and then 

the sealed mould closes and forms the top of the container and keeps 

the container sealed.

Outfeeding

After sealed,the mould is opened,and the containers are totally formed,filled,sealed and is ready to outfeed.Then the machine starts the next cycle.